The biophysical properties of hepatocellular carcinoma (HCC) and surrounding liver tissue were investigated longitudinally in a syngeneic, orthotopic mouse model using noninvasive quantitative imaging. In vivo MR elastography (MRE) and diffusion weighted imaging (DWI) were conducted prior to cancer cell implantation and three times during tumor progression. Our preliminary results suggest the involvement of the surrounding liver in terms of changes in viscoelasticity and restricted water diffusion over 6 weeks post implantation, while the HCC appeared to be stiffer and less viscous than the liver at 6 weeks.
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