Meeting Banner
Abstract #2669

In vivo longitudinal characterization of hepatocellular carcinoma based on viscoelasticity and water diffusivity in an orthotopic mouse model

Karolina Garczyńska1,2, Akvile Häckel1, Eyk Schellenberger1, Anja A. Kühl3, Jürgen Braun4, Lynn Jeanette Savic1, Ingolf Sack1, and Jing Guo1
1Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Department of Veterinary Pathology, Free University of Berlin, Berlin, Germany, 3iPATH.Berlin Core Unit of Charité - Universitätsmedizin Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany, 4Institute of Medical Informatics, Charité Universitätsmedizin Berlin, Berlin, Germany


The biophysical properties of hepatocellular carcinoma (HCC) and surrounding liver tissue were investigated longitudinally in a syngeneic, orthotopic mouse model using noninvasive quantitative imaging. In vivo MR elastography (MRE) and diffusion weighted imaging (DWI) were conducted prior to cancer cell implantation and three times during tumor progression. Our preliminary results suggest the involvement of the surrounding liver in terms of changes in viscoelasticity and restricted water diffusion over 6 weeks post implantation, while the HCC appeared to be stiffer and less viscous than the liver at 6 weeks.

This abstract and the presentation materials are available to members only; a login is required.

Join Here