Abstract #2669

In vivo longitudinal characterization of hepatocellular carcinoma based on viscoelasticity and water diffusivity in an orthotopic mouse model

Karolina Garczyńska^1,2, Akvile Häckel¹, Eyk Schellenberger¹, Anja A. Kühl³, Jürgen Braun⁴, Lynn Jeanette Savic¹, Ingolf Sack¹, and Jing Guo¹

¹Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany, ²Department of Veterinary Pathology, Free University of Berlin, Berlin, Germany, ³iPATH.Berlin Core Unit of Charité - Universitätsmedizin Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴Institute of Medical Informatics, Charité Universitätsmedizin Berlin, Berlin, Germany

Synopsis

The biophysical properties of hepatocellular carcinoma (HCC) and surrounding liver tissue were investigated longitudinally in a syngeneic, orthotopic mouse model using noninvasive quantitative imaging. In vivo MR elastography (MRE) and diffusion weighted imaging (DWI) were conducted prior to cancer cell implantation and three times during tumor progression. Our preliminary results suggest the involvement of the surrounding liver in terms of changes in viscoelasticity and restricted water diffusion over 6 weeks post implantation, while the HCC appeared to be stiffer and less viscous than the liver at 6 weeks.

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