Abstract #2673

Longitudinal hybrid PET/MRI in juvenile-onset Huntington disease (joHD): a pilot study

Maria Eugenia Caligiuri¹, Patrizia Vizza², Pierangelo Veltri³, Francesco Cicone³, Paolo Barberio³, Giuseppe Lucio Cascini³, Eugenia Scaricamazza⁴, Sabrina Maffi⁴, Simone Migliore⁴, Ferdinando Squitieri^4,5, and Umberto Sabatini³

¹Neuroscience Research Center, University "Magna Graecia", Catanzaro, Italy, ²Mater Domini University Hospital, Catanzaro, Italy, ³University "Magna Graecia", Catanzaro, Italy, ⁴IRCCS Casa Sollievo della Sofferenza/CSS-Mendel, San Giovanni Rotondo/Rome, Italy, ⁵Italian League fo Research on Huntington (LIRH Foundation), Rome, Italy

Synopsis

Hybrid PET-MRI is an emerging technique that allows multimodal evaluation of brain structure and function. This study evaluates longitudinal PET-MRI in one patient with stage-2 joHD, to assess changes related to disease progression. This approach might be useful to test the efficacy of disease-modifying drugs.

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