QSM and R2* are quantitative MRI parameters sensitive to iron and myelin content, and their correlation provides further insight into the chemical form of iron. These are the tissue properties which are most affected by Huntington’s disease, besides volumetric changes. We investigate by multiparametric qMRI changes induced by HD in 18 gene-carriers by comparison to matched healthy controls. These qMRI changes are significant in several cortical and subcortical regions and correlate with clinical measures of HD, including CAG mutation length. Although the interpretation of correlations between parameters is not unambiguous, insights into tissue chemical and micro-structure are enabled.
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