QSM, R2* and correlation thereof as qMRI measures of iron and myelin reflect tissue changes in Huntington’s disease
Ana-Maria Oros-Peusquens1, Ravi Dadsena1, Imis Dogan2,3, Kathrin Reetz2,3, and N. Jon Shah1,2,4,5
1Institute of Neuroscience and Medicine INM-4, Research Centre Juelich, Juelich, Germany, 2Department of Neurology, RWTH Aachen University, Aachen, Germany, 3JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Research Centre Juelich, Juelich, Germany, 4Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany, 5Institute of Neuroscience and Medicine 11, INM-11, JARA, Research Centre Juelich, Juelich, Germany
QSM and R2* are quantitative MRI parameters sensitive to iron and myelin content, and their correlation provides further insight into the chemical form of iron. These are the tissue properties which are most affected by Huntington’s disease, besides volumetric changes. We investigate by multiparametric qMRI changes induced by HD in 18 gene-carriers by comparison to matched healthy controls. These qMRI changes are significant in several cortical and subcortical regions and correlate with clinical measures of HD, including CAG mutation length. Although the interpretation of correlations between parameters is not unambiguous, insights into tissue chemical and micro-structure are enabled.
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