Sub-Normothermic Ex-Vivo Perfusion of Porcine Kidney Grafts Improves Energy Metabolism: 31P-MRSI Analysis
Julien Songeon1, Thomas Agius2, Antoine Klauser1,3, Grégoire Longchamp4, Raphael Ruttimann4, Jean-Marc Corpataux2, Alban Longchamp2, and François Lazeyras1,3
1Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland, 2Department of Vascular Surgery, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland, 3Center for Biomedical Imaging (CIBM), Geneva, Switzerland, 4Department of Surgery, Geneva University Hospitals and Medical School, Geneva, Switzerland
Improved preservation strategies for the storage of graft collected after circulatory death could increase the number of kidneys available and improve patient survival. Warm (22 and 37°C) ex-vivo perfusion has emerged as a feasible strategy for organ recovery, but the underlying mechanism remains elusive. Using phosphorus magnetic resonance spectroscopic imaging (31P-MRSI) and histological scoring, we evaluated kidney viability and adenosine triphosphate (ATP) production during sub-normothermic ex-vivo kidney perfusion (SNOP) versus hypothermic machine perfusion (HMP) in a porcine kidney autotransplantation model.
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