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Abstract #2698

MAGiC in glioma: Are pre-contrast quantitative MRI parameters different in tumors with versus without enhancement?

Laura Nunez-Gonzalez1, Karin A. van Garderen1,2, Marion Smits1,2, Jaap Jaspers2, Alejandra Méndez Romero2, Dirk H. J. Poot1, and Juan A. Hernandez-Tamames1,3
1Erasmus MC, Rotterdam, Netherlands, 2Erasmus MC Cancer Institute, Rotterdam, Netherlands, 3TU Delft, Delft, Netherlands


We analyze quantitative values in glioma obtained with MAGiC, which allows obtaining quantitative T1, T2 and PD maps in one single acquisition of less than 6 minutes for a whole brain. The maps were obtained before contrast-agent injection in 14 patients with glioma. We investigated the possibility of characterizing tumor regions based on quantitative maps acquired without contrast-agent. The results showed significant differences among tumoral tissue, tissue with T1w-enhancement, and normal white matter. Voxel-wise, this allowed to distinguish tumoral tissue but did not allow to accurately predicting T1w-enhancement. However, promising results were found predicting T1w-enhancement inside the tumor.

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