Intravoxel incoherent motion (IVIM) can provide information about tissue perfusion in tumours and organs at risk, but the model may not be applicable in all voxels in a region of interest. Here, a model comparison framework is developed, based on comparing IVIM and apparent diffusion coefficient model fits, aiming to identify perfused voxels and quantify the proportion of tissue containing a perfusion component, pIVIM. Technical validation of the framework is performed, with simulations and phantom data showing that SNR and diffusion properties can bias pIVIM, while in vivo parotid gland data show that pIVIM exhibits good repeatability.
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