Understanding inhomogeneous MT (ihMT) in multi-parameter mapping of human brain: Towards larger ihMT, higher resolution, and influence of T1d
Gunther Helms1,2, Lenka Vaculčiaková2, Kerrin J Pine2, Harald E Möller3, and Nikolaus Weiskopf2,4
1Clinical Sciences, Medical Radiation Physics, Lund University, Lund, Sweden, 2Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3NMR Methods & Development Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4Felix Bloch Institute for Solid State Physics, Leipzig University, Leipzig, Germany
Inhomogenous Magnetization Transfer (ihMT), the differential response to irradiation at single and dual frequency offsets, is more complex than MT approaches. Expressing ihMT in terms of MT-saturation (ihMTsat) is a first step to quantification as it corrects for underlying T1 and B1+. Larger ihMTsat was observed for smaller frequency offsets, which is explained using MTsat as proxy for bound pool saturation. For longer TR, ihMTsat increased faster than MTsat indicating recovery of dipolar order as ihMTsat increased super-linearly to 1.1pu in WM and 0.2pu in GM at TR=52ms. ihMTsat mapping in vivo was performed at 1.3mm isotropic resolution.
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