Sequence simulations are used to compare different conventional and boosted saturation schemes and imaging protocols for the purpose of high-resolution ihMTsat cortical imaging. The simulations are constrained to a maximum of four minutes per volume. We find an optimal region for conventional saturation that produces the greatest ihMTsat. For the boosted approach, larger ihMTsat values are found with respect to the conventional approach, and ihMTsat increases with longer TRs. However, the practical utility of the boosted approach for cortical imaging is hampered by a wider PSF associated with higher turbo factors. Simulated ihMTsat findings are supported by in vivo data.
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