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Abstract #2709

Quantitative Magnetization Transfer parametric mapping unbiased by on-resonance saturation and dipolar order contributions

Lucas Soustelle1,2, Thomas Troalen3, Andreea Hertanu1,2, Maxime Guye1,2, Jean-Philippe Ranjeva1,2, Gopal Varma4, David C. Alsop4, Olivier M. Girard1,2, and Guillaume Duhamel1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Siemens Healthcare SAS, Saint-Denis, France, Paris, France, 4Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States


Two major biases in the current qMT methodology arise from i) on-resonance saturation effects induced by readout pulses used in variable flip angle SPGR experiments, and ii) dipolar order effects induced by single-frequency off-resonance saturation pulses leading to a reduced saturation efficiency. In this work, we evaluate these two biases by performing experiments and analyses by accounting for on-resonance saturation in the qMT model and using simultaneous symmetric dual-offset frequency saturation pulses to cancel out dipolar order effects. Results show improvement in the fitting procedure and more accurate estimation of T1,f and MPF values in white and grey matter structures.

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