Two major biases in the current qMT methodology arise from i) on-resonance saturation effects induced by readout pulses used in variable flip angle SPGR experiments, and ii) dipolar order effects induced by single-frequency off-resonance saturation pulses leading to a reduced saturation efficiency. In this work, we evaluate these two biases by performing experiments and analyses by accounting for on-resonance saturation in the qMT model and using simultaneous symmetric dual-offset frequency saturation pulses to cancel out dipolar order effects. Results show improvement in the fitting procedure and more accurate estimation of T1,f and MPF values in white and grey matter structures.
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