Most magnetization transfer experiments are insensitive to the longitudinal relaxation rate of the invisible semi-solid spin pool and it has become common practice to heuristically assume 1/second. This assumption has, however, been challenged recently. Because this parameter is notoriously hard to estimate, previous studies have relied on the analysis of large white matter regions or the entire brain. Here, we explore the ability to estimate this value on a voxel-by-voxel basis with an MR-Fingerprinting-like pulse sequence.
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