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Abstract #2711

Reproducibility of 3D NOE-MTR in a in vivo healthy human brain at 7T

Blake Benyard1, Ravi Prakash Reddy Nanga1, Neil Wilson1, Deepa Thakuri1, Abigail Cember1, and Ravindeer Reddy1
1CAMIPM, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States


Nuclear Overhauser Effect (NOE) is an emerging technique to study mobile macromolecules such as lipids in the gray (GM) and white matter (WM) of the brain. In this work, we optimized the saturation pulse parameters of NOE Magnetization Transfer Ratio (MTR) MRI and investigated its reproducibility on a healthy human volunteer at 7 Telsa. We found that NOE-MTR of GM and WM regions of the brain was highly reproducible (COV<10%) over a three year time span. In addition, a saturation length of 3 to 4 sec provided optimal NOE-MTR contrast from both GM and WM regions of the brain.

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