Nuclear Overhauser Effect (NOE) is an emerging technique to study mobile macromolecules such as lipids in the gray (GM) and white matter (WM) of the brain. In this work, we optimized the saturation pulse parameters of NOE Magnetization Transfer Ratio (MTR) MRI and investigated its reproducibility on a healthy human volunteer at 7 Telsa. We found that NOE-MTR of GM and WM regions of the brain was highly reproducible (COV<10%) over a three year time span. In addition, a saturation length of 3 to 4 sec provided optimal NOE-MTR contrast from both GM and WM regions of the brain.
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