Effects of temperature in the estimation of inhomogeneous magnetic transfer (ihMT) in post-mortem human brain
Francisco J. Fritz1, Gunther Helms2,3, Lenka Vaculčiaková3, Nikolaus Weiskopf3,4, and Siawoosh Mohammadi1,3
1Institut für Systemische Neurowissenschaften, Universitätklinikum Hamburg-Eppendorf, Hamburg, Germany, 2Medical Radiation Physics, IKVL, Lund University, Lund, Sweden, 3Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany
Inhomogeneous magnetic transfer (ihMT) is more sensitive to myelin macromolecules than standard MT proxies. Measuring ihMT in the multi-parameter mapping protocol allows calculating ihMT from MT saturation (MTsat) maps and thus inherently correct for the undesired dependencies on flip angle and the longitudinal relaxation rate. Further validation of this new ihMT metric requires measurement of MPM-based ihMT of human post-mortem material. Here, we showed that ihMT of a whole human post-mortem brain is feasible but can lead to temperature increase in the specimen, which is particularly pronounced in white matter.
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