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Abstract #2714

Simultaneous Mapping of B0, B1 and T1 Using a CEST-like Pulse Sequence and Neural Network Analysis

Patrick Schuenke1, Kerstin Heinecke1, George Henrik Narvaez1, Moritz Zaiss2, and Christoph Kolbitsch1
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2Department of Neuroradiology, Friedrich- Alexander Universität Erlangen- Nürnberg, University Hospital Erlangen, Erlangen, Germany


Obtaining isolated effects in Chemical Exchange Saturation Transfer (CEST) MRI requires the correction for the influence of B0- and B1-inhomogeneities and the T1 relaxation time during post-processing. We present an extended approach for simultaneous mapping of B0, B1 and T1 using a CEST-like pulse sequence and a regularized neural network-based analysis that provides additional uncertainty estimations. We demonstrate the in vitro and in vivo applicability of the proposed approach, which is trained using simulated data and confirm its accordance with established reference methods.

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