Simultaneous imaging of positive and negative chemical exchange contrast: On the implementation of the RACETE-technique on a clinical 3T-system
Verena Schirmer1, Maximilian Gram1,2, Petra Albertova1, Simon Mayer1,3, Martin Blaimer4, Peter Michael Jakob1, and Fabian Tobias Gutjahr1
1Experimental Physics 5, University of Würzburg, Würzburg, Germany, 2Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, 3Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany, 4Magnetic Resonance and X-ray Imaging Department Fraunhofer IIS, Fraunhofer Institute for Integrated Circuits IIS, Würzburg, Germany
Contrary to the basic principle of CEST, the RACETE technique allows for the direct detection of positive chemical exchange contrast. This method, which was previously demonstrated only under ultra-high field conditions at 7T-17.5T, has now successfully been implemented on a clinical 3T scanner in initial phantom experiments. Furthermore, we present a novel dual-contrast RACETE-technique for simultaneous imaging of the positive RACETE and the negative CEST contrast.
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