Abstract #2719

Simultaneous imaging of positive and negative chemical exchange contrast: On the implementation of the RACETE-technique on a clinical 3T-system

Verena Schirmer¹, Maximilian Gram^1,2, Petra Albertova¹, Simon Mayer^1,3, Martin Blaimer⁴, Peter Michael Jakob¹, and Fabian Tobias Gutjahr¹

¹Experimental Physics 5, University of Würzburg, Würzburg, Germany, ²Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, ³Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany, ⁴Magnetic Resonance and X-ray Imaging Department Fraunhofer IIS, Fraunhofer Institute for Integrated Circuits IIS, Würzburg, Germany

Synopsis

Contrary to the basic principle of CEST, the RACETE technique allows for the direct detection of positive chemical exchange contrast. This method, which was previously demonstrated only under ultra-high field conditions at 7T-17.5T, has now successfully been implemented on a clinical 3T scanner in initial phantom experiments. Furthermore, we present a novel dual-contrast RACETE-technique for simultaneous imaging of the positive RACETE and the negative CEST contrast.

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