Compared to the traditional circular polarization (CP) transmission mode, parallel transmission (pTx) excitation allows significant gains in contrast and homogeneity for Chemical Exchange Saturation Transfer (CEST) imaging. Using an in-house developed CEST-EPI sequence incorporating a pTx optimized CEST saturation block, we show that both tailored and universal pTx pulses provide significant improvement at 7T for APT-CEST, GluCEST and GlucoCEST imaging and enable saturation powers unattainable with CP.
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