Abstract #2732

Convection triggers local MR signal loss during proton beam irradiation of liquid water phantoms

Juliane Peter^1,2, Sebastian Gantz^1,2, Leonhard Karsch^1,2, Jörg Pawelke^1,2, and Aswin Hoffmann^1,2,3

¹OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ²Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology – OncoRay, Dresden, Germany, ³Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Synopsis

MRI-based proton beam visualisation in water has proven feasible in exploratory irradiation experiments performed on a first research prototype in-beam MRI system. Beam-induced convection was hypothesised to be implicated into MR signal loss observed within the beam volume. In this study, this hypothesis was tested in liquid water-filled phantoms by suppression of convection-induced motion using mechanical barriers and temperature control of water expansivity. In absence of convection-induced motion, no beam-induced signal changes occurred, supporting the hypothesis that convection triggers local MR signal loss during proton beam irradiation. The elucidation of the exact mechanism of convection-induced signal loss requires further investigation.

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