Abstract #2733

Effect of circadian rhythm on brain NAD: an MRS study at 7 T

Zhiwei Huang¹, Bernard Cuenoud², Mickael Hartweg³, Daniel Wenz¹, and Lijing Xin¹

¹Center for Biomedical Imaging, EPFL, Ecublens, Switzerland, ²Translation Research, Nestlé Health Science, Lausanne, Switzerland, ³Clinical Research Unit, Nestlé Research and Development, Lausanne, Switzerland

Synopsis

Our understanding of circadian rhythm has expanded to provide molecular insights into physiology and disease since the discovery of circadian clock.Pre-clinical experiments have shown that circadian rhythm is linked with the Nicotinamid Adenine Dinucleotide (NAD) levels and the redox ratio. However, clinical data is still lacking. In this study, we aim to study the effect of circadian rhythm on NAD levels in the human brain. By measuring the NAD levels in the occipital lobe with 31P-MRS, preliminary interim results suggest a negative correlation trend between cortisol level and total NAD level.

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