Abstract #2735

Sex-specific effects of prenatal tobacco exposure on cognitive and brain morphometry measures in preadolescent children

Pedro Juan Rodriguez Rivera¹, Amal Isaiah ^1,2,3, Thomas Ernst^1,4, Christine Cloak¹, Huajun Liang¹, and Linda Chang^1,4,5

¹Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Department of Otorhinolaryngology, University of Maryland School of Medicine, Baltimore, MD, United States, ³Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States, ⁴Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States, ⁵Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Prenatal tobacco exposure (PTE) can affect the offspring cognitive and brain development outcomes. Our study evaluated children who had PTE in the Adolescent Brain and Cognitive Development (ABCD) study and found poorer overall cognitive scores, especially working memory scores, lower cortical surface areas and subcortical volumes, with smaller surface areas in the posterior cingulate (PCC) and entorhinal cortices, the lingual and inferior parietal gyri, and abnormally smaller volumes in the thalamus and nucleus accumbens. Furthermore, we found that only PTE-girls had significantly smaller surface areas in the postcentral gyrus, while only PTE-boys had smaller volumes in the posterior corpus callosum.

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