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Abstract #2735

Sex-specific effects of prenatal tobacco exposure on cognitive and brain morphometry measures in preadolescent children

Pedro Juan Rodriguez Rivera1, Amal Isaiah 1,2,3, Thomas Ernst1,4, Christine Cloak1, Huajun Liang1, and Linda Chang1,4,5
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Department of Otorhinolaryngology, University of Maryland School of Medicine, Baltimore, MD, United States, 3Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States, 4Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States, 5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Prenatal tobacco exposure (PTE) can affect the offspring cognitive and brain development outcomes. Our study evaluated children who had PTE in the Adolescent Brain and Cognitive Development (ABCD) study and found poorer overall cognitive scores, especially working memory scores, lower cortical surface areas and subcortical volumes, with smaller surface areas in the posterior cingulate (PCC) and entorhinal cortices, the lingual and inferior parietal gyri, and abnormally smaller volumes in the thalamus and nucleus accumbens. Furthermore, we found that only PTE-girls had significantly smaller surface areas in the postcentral gyrus, while only PTE-boys had smaller volumes in the posterior corpus callosum.

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