Abstract #2737

ACUTE CAFFEINE ADMINISTRATION AS A CONFOUND FOR q-MRI and volumetric MRI STUDIES

Vishaal Sumra^1,2,3 and Sofia Chavez^1,2,4

¹Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ²Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada, ³Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada, ⁴Department of Psychiatry, University of Toronto, Toronto, ON, Canada

Synopsis

Changes in cerebral blood flow (CBF) have the ability to confound structural and quantitative MRI studies. Caffeine is widely consumed and leads to strong decreases in CBF. Moderate caffeine users were scanned before and after caffeinated and decaffeinated coffee over two separate days. Percentage change in CBF maps, quantitative T1 maps, and estimates of grey matter volume (GMV) were assessed for the caffeinated coffee and decaffeinated coffee days. Robust decreases in CBF were observed, along with changes in T1 maps and estimates of GMV. Caffeine intake should be considered in studies relying on structural and quantitative MRI measures.

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