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Abstract #2739

Diffusion microstructure measurements across the brain and lifespan

Benjamin T Newman1 and T. Jason Druzgal1
1Department of Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States


Understanding how the brain develops, matures, ages, and declines is one of the fundamental questions facing neuroscience1–3. Recent advances in diffusion microstructure analysis have allowed for detailed descriptions of neuronal change. However, it is essential that findings from these studies are appropriately contextualized to general age-related changes in the brain4,5. This study uses 3-tissue constrained spherical deconvolution (3T-CSD) to examine the relationship between brain diffusion microstructure and chronological age in a number of gross anatomical structures, subcortical gray matter, and cortex while additionally evaluating lateral differences in microstructural measurements. The results should serve as a benchmark for diffusion microstructure studies.

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