Evaluating the feasibility of quantifying longitudinal microstructural changes in mild traumatic brain injury (mTBI) with MAP-MRI
Priyanka M Nadar1,2, Alexandru V Avram3,4, Luca Marinelli5, and Peter J Basser3
1Clinical Center, NIH, Bethesda, MD, United States, 2Drexel University College of Medicine, Philadelphia, PA, United States, 3NICHD, NIH, Bethesda, MD, United States, 4Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States, 5Global Research, General Electric, Niskayuna, NY, United States
Mean Apparent Propagator (MAP) MRI, an expansion of diffusion tensor imaging (DTI), explicitly measures the distribution of net 3D displacements of diffusing water molecules, providing better delineation of crossing white matter fiber tracts. This characteristic may be useful in characterizing unseen microstructural damage in patients with mild traumatic brain injuries whose clinical imaging scans are otherwise normal. An image processing pipeline for using mean apparent propagator (MAP) MRI to analyze diffusion weighted images in mTBI patients has been validated in healthy controls and shown to generate reliable data for patient brain scans.
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