Abstract #2751
Cancer-Induced Metabolic Reprogramming of the Spleen
James D Barnett1, Marie-France Penet1,2, Raj Kumar Sharma1, Balaji Krishnamachary1, Yelena Mironchik1, and Zaver Bhujwalla1,2,3
1Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
Synopsis
Our findings demonstrate that tumors drive metabolic alterations in the spleen. These metabolic changes may contribute to immune suppression and poor prognosis.
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