A hyperpolarised [1-13C]lactate solution prepared by dynamic nuclear polarization at 7T and 1.4K using photo-irradiated alpha-ketoglutarate as the polarizing agent was injected at low dose in healthy rodents to allow measuring in vivo metabolism in the rodent brain and liver at physiological concentration. As a result of the large 13C polarisation, it was possible to detect metabolic products of [1-13C]lactate in vivo, including [1-13C]pyruvate and 13C-bicarbonate. The observed pyruvate-to-lactate ratios were commensurate with in vitro values previously reported in the literature. The purely endogenous composition of the solution offers the possibility of performing similar measurements in humans.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords