We evaluated the reproducibility of liver ADC measurements across acquisition parameters using low spatial resolution DWI with M1 optimized diffusion imaging waveforms (MODI) and the routinely clinically utilized monopolar (MONO) waveforms. We also evaluated the effects of various M1 values as well as those of breath-hold and respiratory-triggering on MODI-DWI liver ADC measurements at lower resolutions than utilized in clinical practice. MONO-DWI liver ADC suffered from bias and resolution-dependence in the left lobe while MODI-DWI liver ADC did not demonstrate this effect. MODI-DWI liver ADC did not demonstrate bias with respect to resolution, M1, or breathing technique.
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