Abstract #2765
Comparison of Centralized R2* Mapping Algorithms to Vendor R2* Mapping in a Multi-Center, Multi-Vendor Liver Iron Overload Study
Gregory Simchick1,2, Ruiyang Zhao1,2, Qing Yuan3, Mounes Aliyari Ghasabeh4, Stefan Ruschke5, Dimitrios C Karampinos5, David Harris1, Ryan J Mattison6, Michael R Jeng7, Ivan Pedrosa3,8, Ihab R Kanel3, Sheryas Vasanawala9, Takeshi Yokoo3,8, Scott B Reeder1,2,6,10,11, and Diego Hernando1,2
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Radiology, The John Hopkins University, Baltimore, MD, United States, 5Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 6Medicine, University of Wisconsin-Madison, Madison, WI, United States, 7Pediatrics - Hematology & Oncology, Stanford University, Palo Alto, CA, United States, 8Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 9Radiology, Stanford University, Palo Alto, CA, United States, 10Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 11Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States
Synopsis
Recently, a multi-center, multi-vendor study evaluating the reproducibility of R2* vs liver iron concentration (LIC) calibrations was completed, based on a centralized offline R2* reconstruction. However, the relationship between the offline reconstructed R2* maps and the online vendor-provided R2* maps remains unknown. In this work, subjects were recruited at four centers and imaged using 1.5T and 3T MRI scanners from three vendors. R2* maps were obtained using various offline reconstructions and compared to the online vendor reconstructions to determine R2* ranges of agreement. This may enable improved clinical interpretation of vendor R2* measurements using emerging offline R2*-LIC calibrations.
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