Abstract #2766

Liver response to fasting and isocaloric high-carbohydrate refeeding in lean and obese women

Petr Sedivy¹, Tereza Dusilova¹, Barbora Setinova¹, Monika Dezortova¹, Martin Burian¹, Eva Krauzova², Michaela Siklova³, Lenka Rossmeislova³, Michal Koc³, Milan Hajek¹, and Jan Kovar⁴

¹MR unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Department of Internal Medicine, Third Faculty of Medicine, Charles University, University Hospital Královské Vinohrady, Prague, Czech Republic, ³Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Synopsis

Our MRS and MRI study investigates the liver response to two days of fasting followed by two days of isocaloric high carbohydrate refeeding in lean and obese women. Hepatic fat content increased after fasting in lean women whereas it did not change in obese women. The tendency to lose or accumulate fat during fasting could be related to the overall initial hepatic fat content. Moreover, liver volume significantly decreased and increased during fasting and refeeding, respectively.

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