Liver response to fasting and isocaloric high-carbohydrate refeeding in lean and obese women
Petr Sedivy1, Tereza Dusilova1, Barbora Setinova1, Monika Dezortova1, Martin Burian1, Eva Krauzova2, Michaela Siklova3, Lenka Rossmeislova3, Michal Koc3, Milan Hajek1, and Jan Kovar4
1MR unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Department of Internal Medicine, Third Faculty of Medicine, Charles University, University Hospital Královské Vinohrady, Prague, Czech Republic, 3Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic, 4Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Our MRS and MRI study investigates the liver response to two days of fasting followed by two days of isocaloric high carbohydrate refeeding in lean and obese women. Hepatic fat content increased after fasting in lean women whereas it did not change in obese women. The tendency to lose or accumulate fat during fasting could be related to the overall initial hepatic fat content. Moreover, liver volume significantly decreased and increased during fasting and refeeding, respectively.
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