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Abstract #2768

Mouse models of diet-induced obesity allow for optimal magnetic resonance measurements of brown adipose tissue activation and heterogeneity

Michal R Tomaszewski1, Hyking Haley1, Xiangjun Meng1, and Corin O Miller1
1Translational Imaging, Merck & Co, West Point, PA, United States


Robust measurement of brown and white adipose tissue physiology in response to treatment is essential in pharmaceutical research. In this work we propose for the first time that the diet-induced obesity (DIO) mouse model can be successfully used in conjunction with both Multi Gradient Echo and Fast Spin Echo based methods for sensitive characterization of changes in brown (BAT) and white adipose tissue following pharmaceutical intervention, showing more consistent responses than lean mice. Spatial heterogeneity within BAT and response dynamics are reported, relevant for future use of the model and the proposed framework in weight loss and drug characterization studies.

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