Robust measurement of brown and white adipose tissue physiology in response to treatment is essential in pharmaceutical research. In this work we propose for the first time that the diet-induced obesity (DIO) mouse model can be successfully used in conjunction with both Multi Gradient Echo and Fast Spin Echo based methods for sensitive characterization of changes in brown (BAT) and white adipose tissue following pharmaceutical intervention, showing more consistent responses than lean mice. Spatial heterogeneity within BAT and response dynamics are reported, relevant for future use of the model and the proposed framework in weight loss and drug characterization studies.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords