Robust measurement of brown and white adipose tissue physiology in response to treatment is essential in pharmaceutical research. In this work we propose for the first time that the diet-induced obesity (DIO) mouse model can be successfully used in conjunction with both Multi Gradient Echo and Fast Spin Echo based methods for sensitive characterization of changes in brown (BAT) and white adipose tissue following pharmaceutical intervention, showing more consistent responses than lean mice. Spatial heterogeneity within BAT and response dynamics are reported, relevant for future use of the model and the proposed framework in weight loss and drug characterization studies.
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