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Abstract #2787

APT-CEST Scan-Rescan Reproducibility in Healthy Volunteers and Brain Glioma Patients at 3 Tesla

Ivar J.H.G. Wamelink1, Beatriz Padrela1, Joost P.A. Kuijer1, Yi Zhang2, Frederik Barkhof1,3, Henk J.M.M. Mutsaerts1, Elsmarieke van de Giessen1, and Vera C. Keil1
1Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam Medisch Centrum, Amsterdam, Netherlands, 2Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China, 3UCL Institutes of Neurology and Healthcare Engineering, London, United Kingdom


Amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI is a potentially useful clinical technique to image brain tumors, but its reproducibility was not yet investigated in detail. Our 3T scan-rescan protocol on volunteers and glioma patients revealed high within-session and slightly lower in-between-session and between-day reproducibility, with highest reproducibility occipitally and centrally in the brain and lowest at the skull base. The within-session reproducibility for patients was also good, both intratumoral and extratumoral. These results show that APT-CEST at 3T MRI renders reproducible values allowing for clinical monitoring of metabolic brain tumors.

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