Repeatability of ultra-high-resolution Multi-Parametric Mapping across five 7T sites
siya sherif1, Ali Aghaeifar2,3, Kerrin Pine4, Belinda Ding5, Maryam Seif6, Evelyne Balteau1, Daniel Nanz7,8, Christine Bastin1, Eric Salmon1,9, Pierre Maquet1,9, Gilles Vandewalle1, Christopher T Rodgers 5, Patrick Freund6, Nikolaus Weiskopf4,10, Christophe Phillips1,11, and Martina F Callaghan3
1GIGA-Cyclotron Research Centre - In Vivo Imaging, University of Liège, Liège, Belgium, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 3Wellcome Centre for Human Neuroimaging, University College London, London, United Kingdom, 4Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 5Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, 6Spinal cord injury Center, University of Zurich, Zurich, Switzerland, 7Swiss Center for Musculoskeletal Imaging, Zurich, Switzerland, 8University of Zurich, Zurich, Switzerland, 9Department of Neurology, University Hospital of Liège, Liège, Belgium, 10Felix Bloch Institute for Solid State Physics, Leipzig University, Leipzig, Germany, 11GIGA - In Silico Medicine, University of Liège, Liège, Belgium
Repeatability is key to the utility of quantitative MRI, which promises standardised measures with biological relevance. Here we tested a candidate ultra-high resolution (0.6mm isotropic) multi-parameter mapping protocol at five 7T sites. Repeatability was good, with B0 and B1+ field inhomogeneities being the limiting factor. MTsat had the lowest repeatability and PD the highest. R1 and R2* were intermediate. Repeatability was also lowest in temporal and occipital cortices. These observations were consistent across sites.
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