We investigated the reproducibility of multiparameter mapping (MPM) using multi-echo skipped-CAIPI 3D-EPI at 3T. Compared to >15 minutes of FLASH-MPM, EPI-MPM under 3 minutes achieved considerably high repeatability. In only one fifth of the total scan time of FLASH, the resulting CoVs of EPI were only 1.2-2.2 times larger than FLASH for R1, PD and MTsat, while the CoV of EPI for R2* was even smaller. Minor differences of the observed parameter estimates can be attributed to the intrinsic difference between EPI and FLASH sequence timing.
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