Heterogeneity of ASL perfusion MRI in low-grade paediatric glioma as imaging biomarker to assess treatment effect
Lejla Alic1, Sanneke C Willekens1,2, Henk-Jan M.M. Mutsaerts2, Jan Petr3, Netteke A.Y.N. Schouten-van Meeteren4,5, Maarten M.H. Lequin6, and Evita E.C. Wiegers2
1Magnetic Detection & Imaging Group, University of Twente, Enschede, Netherlands, 2Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 3Helmholtz-Zentrum Dresden-Rossendorf, Institute for Radiopharmaceutical Cancer Research, Dresden, Germany, 4Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam, Netherlands, 5Department of Neuro-oncology, Princess Máxima Centre, Utrecht, Netherlands, 6Radiology, University Medical Center Utrecht, Utrecht, Netherlands
ASL-MRI is reported as an option to assess potentially heterogeneous physiological processes important for tumour treatment. Therefore, we explored the heterogeneity in normalised CBF as an imaging biomarker for assessment of treatment effect in pLGG. There is a noticeable effect of chemotherapy observed as a change in texture of healthy appearing brain tissue. A high difference in texture between treated and non-treated patients for non-enhancing tumour part is observed, suggesting that texture, based on co-occurrence matrices, is suitable as an imaging biomarker for assessment of treatment effect in pLGG.
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