Reduced field-of-view multi-shell DWI of the sciatic nerve: A reproducibility assessment
Ratthaporn Boonsuth1, Rebecca S Samson1, Francesco Grussu1,2, Marco Battiston1, Torben Schneider3, Masami Yoneyama4, Ferran Prados1,5,6, Carmen Tur1,7, Sara Collorone1, Rosa Cortese1, Claudia AM Gandini Wheeler-Kingshott1,8,9, and Marios C Yiannakas1
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 2Radiomics Group, Vall d’Hebron Institute of Oncology, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 3Philips Healthcare, Guildford, Surrey, United Kingdom, 4Philips Japan, Minatoku, Tokyo, Japan, 5Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 6E-Heath Centre, Universitat Oberta de Catalunya, Barcelona, Spain, 7Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron Institute of Research, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, 8Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 9Brain Connectivity Research Centre, IRCCS Mondino Foundation, Pavia, Italy
Advanced diffusion-weighted imaging (DWI) methods are powerful diagnostic and research tools when applied in the central nervous system (CNS). However, the use of DWI methods to study individual nerves outside the CNS in vivo, such as the sciatic nerve, has been hampered by a number of technical challenges. In this study, we explore the feasibility of acquiring multi-shell DWI metrics in the sciatic nerve using reduced field-of-view echo planar imaging and report results from a reproducibility assessment in in healthy controls.
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