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Abstract #2798

Within‐subject reliability of proton density estimation using quantitative magnetic resonance imaging

Karthik R Sreenivasan1, Dietmar Cordes1, Virendra Mishra1, and Le H Hua1
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States


New advances in quantitative MRI (qMRI) techniques provide basic MRI properties such as proton density (PD) that can act as a direct surrogate of the tissue integrity in the voxel. PD may help demonstrate differences on an individual level in patients with multiple sclerosis. In this study, we wanted to compare the within-subject reproducibility of qMRI-based PD measures. Variability in the estimated PD was low and fell within the limits for reliability. These results suggest that in-vivo estimates of PD using qMRI are reproducible within the subject in the same scanner and could play a vital role in clinical studies.

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