Abstract #2799

Molecular imaging of breast cancer by chemical exchange saturation transfer (CEST) MRI of glucosamine: first human experience

Michal Rivlin¹, Debbie Anaby^2,3, Noam Nissan^2,3, Moritz Zaiss⁴, Anagha Deshmane⁵, Miri Sklair-Levy^3,6, and Gil Navon¹

¹School of Chemistry, Tel-Aviv University, Tel-Aviv, Israel, ²Department of Diagnostic Imaging, Sheba Medical Center, Ramat-Gan, Israel, ³The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ⁴Department of Neuroradiology, University Clinic Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁵Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany, ⁶Meirav High Risk Clinic, Department of Diagnostic Imaging, Sheba Medical Center, Ramat-Gan, Israel

Synopsis

In preclinical experiments in implanted breast cancer tumors in mice, glucosamine (GlcN) exhibited enhanced chemical exchange saturation transfer (CEST) MRI signals. Moving toward clinical application, considering the excellent safety profile of GlcN, we examined the feasibility of using the GlcN CEST method to detect human breast cancer on a 3T clinical scanner. Here we report significant CEST MRI signals resulting from the exchangeable protons of GlcN hydroxyls, amine/amide residues as well as nuclear Overhauser enhancement (NOE). Thus, CEST MRI using GlcN has the potential to detect tumors and report their activity, without the use of a gadolinium contrast agent.

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