A preliminary investigation into the contribution of Amines to the CEST contrast at 2 ppm and 3 ppm in high-grade gliomas at 7T
Bárbara Schmitz Abecassis1, Chloé Najac1, Jeroen de Bresser 1, Linda Dirven2,3, Martin J.B. Taphoorn2,3, Matthias J.P. van Osch1, Johan A.F. Koekkoek2,3, and Ece Ercan1
1Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Neurology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Neurology, Haaglanden Medical Center, The Hague, Netherlands
CEST allows to non-invasively image metabolites and proteins, and the role of APT and NOE CEST in gliomas has been widely investigated. On the other hand, the contribution of amines to the CEST signal at 2 and 3 ppm, and its relationship to creatine and glutamate concentrations, remain unclear. We evaluated the amine CEST contrast in tumor and contralateral white matter in three glioma patients, and compared it to the MRS data. Overall we found a decrease in amine CEST alongside a decrease in total creatine and glutamate in the tumor compared to the contralateral white matter.
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