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Abstract #2802

Improving clinical 3T Amide Proton Transfer weighted contrast in Brain Tumors by using a novel spatial denoising method

Feriel Romdhane1, Dario Livio Longo1, Christos Papageorgakis2, Eleni Firippi2, Laura Mancini3,4, Sotirios Bisdas3,4, Moritz Zaiss5, and Stefano Casagranda2
1Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), Torino, Italy, 2Department of Research & Innovation, Olea Medical, La Ciotat, France, 3Lysholm Department of Neuroradiology, University College of London Hospitals NHS Foundation Trust, London, United Kingdom, 4Institute of Neurology UCL, London, United Kingdom, 5Department of Neuroradiology, University Clinic Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany


Amide Proton Transfer weighted (APTw) imaging is a promising MR molecular technique for characterizing brain tumors on clinical 3T scanners. However, improving the APT weighted contrast is crucial to translate this approach to clinical practice. In this work we investigated a novel spatial denoising filter in synthetic and clinical APTw data of brain tumor patients.

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