Abstract #2802

Improving clinical 3T Amide Proton Transfer weighted contrast in Brain Tumors by using a novel spatial denoising method

Feriel Romdhane¹, Dario Livio Longo¹, Christos Papageorgakis², Eleni Firippi², Laura Mancini^3,4, Sotirios Bisdas^3,4, Moritz Zaiss⁵, and Stefano Casagranda²

¹Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), Torino, Italy, ²Department of Research & Innovation, Olea Medical, La Ciotat, France, ³Lysholm Department of Neuroradiology, University College of London Hospitals NHS Foundation Trust, London, United Kingdom, ⁴Institute of Neurology UCL, London, United Kingdom, ⁵Department of Neuroradiology, University Clinic Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Synopsis

Amide Proton Transfer weighted (APTw) imaging is a promising MR molecular technique for characterizing brain tumors on clinical 3T scanners. However, improving the APT weighted contrast is crucial to translate this approach to clinical practice. In this work we investigated a novel spatial denoising filter in synthetic and clinical APTw data of brain tumor patients.

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