Abstract #2803

Presaturation pulse shape enables shifting the pH sensitivity of guanidyl CEST-MRI for absolute pH mapping at 9.4 T

Philip S Boyd^1,2, Lilli Diederichs^1,2, Johannes Breitling¹, Mark E Ladd^1,2,3, Peter Bachert^1,2, and Steffen Goerke¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, ³Faculty of Medicine, University of Heidelberg, Heidelberg, Germany

Synopsis

In this study, we present a method for absolute pH mapping using the guanidyl CEST signal. The method is an extension of a previous approach that allowed compensating for various concomitant effects other than pH, but additionally required measuring the amide signal. By optimizing the pulse shape of the pulsed presaturation the pH sensitivity of the guanidyl signal could now be shifted to the physiologically relevant range around pH 7.1. The shift of sensitivity was verified experimentally in a multi-pH creatine phantom at 9.4T. Thus, CEST-based pH mapping with exceptional specificity is now also possible using only the guanidyl signal.

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