Abstract #2804

Comparison study between APT-weighted and relaxation-compensated CEST-MRI in human glioma at 3T

Florian Kroh^1,2, Johannes Breitling¹, Nikolaus von Knebel Doeberitz³, Heinz-Peter Schlemmer^3,4, Mark E. Ladd^1,2,4, Peter Bachert^1,2, Daniel Paech^3,5, and Steffen Goerke¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, ³Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴Faculty of Medicine, University of Heidelberg, Heidelberg, Germany, ⁵Division of Neuroradiology, University Hospital Bonn, Bonn, Germany

Synopsis

Although the underlying mechanisms of APT-weighted (APTw) CEST-MRI are not completely understood, it has been shown to provide valuable information for brain tumor imaging at 3T. To gather more information about the mechanisms, the APTw signal was correlated to relaxation-compensated CEST contrasts in 21 postoperative human glioma patients. A correlation, although being only moderate, was found for the relaxation-compensated APT contrast in the contrast enhancing (CE) tumor region, but not for other tissues, nor rNOE or MT contrast. Differentiation of the CE tumor and normal appearing white matter was strongly dependent on the selective relaxation-compensated CEST evaluation method.

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