Comparison study between APT-weighted and relaxation-compensated CEST-MRI in human glioma at 3T
Florian Kroh1,2, Johannes Breitling1, Nikolaus von Knebel Doeberitz3, Heinz-Peter Schlemmer3,4, Mark E. Ladd1,2,4, Peter Bachert1,2, Daniel Paech3,5, and Steffen Goerke1
1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 3Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Faculty of Medicine, University of Heidelberg, Heidelberg, Germany, 5Division of Neuroradiology, University Hospital Bonn, Bonn, Germany
Although the underlying mechanisms of APT-weighted (APTw) CEST-MRI are not completely understood, it has been shown to provide valuable information for brain tumor imaging at 3T. To gather more information about the mechanisms, the APTw signal was correlated to relaxation-compensated CEST contrasts in 21 postoperative human glioma patients. A correlation, although being only moderate, was found for the relaxation-compensated APT contrast in the contrast enhancing (CE) tumor region, but not for other tissues, nor rNOE or MT contrast. Differentiation of the CE tumor and normal appearing white matter was strongly dependent on the selective relaxation-compensated CEST evaluation method.
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