Although the underlying mechanisms of APT-weighted (APTw) CEST-MRI are not completely understood, it has been shown to provide valuable information for brain tumor imaging at 3T. To gather more information about the mechanisms, the APTw signal was correlated to relaxation-compensated CEST contrasts in 21 postoperative human glioma patients. A correlation, although being only moderate, was found for the relaxation-compensated APT contrast in the contrast enhancing (CE) tumor region, but not for other tissues, nor rNOE or MT contrast. Differentiation of the CE tumor and normal appearing white matter was strongly dependent on the selective relaxation-compensated CEST evaluation method.
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