Alzheimer’s Disease (AD) is defined biologically by the presence of neuritic plaques composed of amyloid-in β (Aβ)peptides and dystrophic neurites, neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein, and neuronal loss. In this study, CEST experiments were performed on purified full-length tau monomer and aggregated tau fibrils. We found differences in CEST z-spectra between purified full-length tau monomers and aggregated tau fibrils. This finding substantiates the potential use of CEST for ultimately monitoring disease progression in AD patients
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