Abstract #2806

Healthy vs pathological tau can be differentiated by CEST NMR

Fang Frank Yu¹, James Ratnakar², Jonathan A Brewer¹, Brian Hitt³, A Dean Sherry^1,2, and Elena Vinogradov^1,2

¹Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Advanced Imaging Reseach Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Neurology, University of California, Irvine Medical Center, Irvine, CA, United States

Synopsis

Alzheimer’s Disease (AD) is defined biologically by the presence of neuritic plaques composed of amyloid-in β (Aβ)peptides and dystrophic neurites, neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein, and neuronal loss. In this study, CEST experiments were performed on purified full-length tau monomer and aggregated tau fibrils. We found differences in CEST z-spectra between purified full-length tau monomers and aggregated tau fibrils. This finding substantiates the potential use of CEST for ultimately monitoring disease progression in AD patients

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