Healthy vs pathological tau can be differentiated by CEST NMR
Fang Frank Yu1, James Ratnakar2, Jonathan A Brewer1, Brian Hitt3, A Dean Sherry1,2, and Elena Vinogradov1,2
1Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Reseach Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Neurology, University of California, Irvine Medical Center, Irvine, CA, United States
Alzheimer’s Disease (AD) is defined biologically by the presence of neuritic plaques composed of amyloid-in β (Aβ)peptides and dystrophic neurites, neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein, and neuronal loss. In this study, CEST experiments were performed on purified full-length tau monomer and aggregated tau fibrils. We found differences in CEST z-spectra between purified full-length tau monomers and aggregated tau fibrils. This finding substantiates the potential use of CEST for ultimately monitoring disease progression in AD patients
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