The influence of fat suppression methods and image reconstruction parameters on the apparent diffusion coefficient (ADC) in uninvolved bone marrow was assessed in 18 patients with myeloma. ADC estimates from diffusion-weighted MRI acquired using spectral adiabatic inversion recovery (SPAIR) fat suppression were significantly lower than DW-MRI with short-tau inversion recovery (STIR). ADC estimates were significantly lower in data reconstructed using sum-of-squares coil-combination mode compared with adaptive combine, but there was no difference between additional reconstruction filters (raw, elliptical). These results show that differences between imaging protocols should be considered when comparing ADC estimates with established ranges and in multi-centre studies.
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