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Abstract #2840

Removal of perfusion lag structure before ICA-FIX cleaning boosts both reproducibility and between-subject similarity in fcMRI

Toshihiko Aso1 and Takuya Hayashi1
1Laboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan


Removal of the perfusion lag structure in the fMRI signal was combined with independent component analysis (ICA)-based cleaning to evaluate its effect on test-retest reproducibility. In HCP test-retest data from 40 subjects, either treatment and the combined method effectively improved the reproducibility of functional connectivity. However, the effect was more evident in between-subject similarity of the connectivity pattern than within-subject similarity. This finding suggests that the perfusion lag structure may be one of the sources of between-subject variability, that may degrade the functional connectivity.

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