Mechanisms of relaxation in blood - Nuclear magnetic resonance dispersion profile of rat’s blood, plasma, and red cells at different temperatures
Mohsine Mekhfi 1, Aimé Labbé 1, Dimitri Kereselidze1, Erwan Selingue 2, Lionel Broche3, Anne-Laure Rollet 4, and Marie Poirier-quinot1
1Université Paris Saclay, CEA, CNRS, Inserm, Laboratoire d’Imagerie biomédicale multimodale Paris Saclay (BioMaps), Orsay, France, 2Université Paris-Saclay, CEA, CNRS, Baobab, NeuroSpin, Gif-sur-Yvette, France, 3Aberdeen Biomedical Imaging Centre, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, UK, Aberdeen, Scotland, 4Laboratoire PHysico-chimie des Electrolytes et Nanosystèmes InterfaciauX, PHENIX, Sorbonne Université, CNRS, Paris, France
Measuring whole blood relaxation time is as a reliable diagnosis tool. Usually, one compartmental model is used to fit data, which seems a very simplistic approach considering the complexity of blood. The aim of this work is to test the validity of this assumption by studying the relaxation rate of whole blood, plasma and red blood cells (rbc) of rats at different temperatures. The whole blood is well described by a two-compartment approach, one corresponding to plasma and another for red blood cells. Once frozen, there is only one relaxation rate population, which is considered to be the rbc population.
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