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Abstract #2862

T2 measured with multiple spin-echo depends on echo spacing as well as orientation

Jonathan Doucette1,2, Manuel Bauer1,3, Lara Bartels1,2, Alexander Jaffray1,2, and Alexander Rauscher1,2,4,5
1UBC MRI Research Centre, Vancouver, BC, Canada, 2Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 3Institute for Physical Chemistry, Albert-Ludwigs-University, Freiburg, Germany, 4Radiology, University of British Columbia, Vancouver, BC, Canada, 5Pediatrics, University of British Columbia, Vancouver, BC, Canada


The MRI signal in white matter tissue is composed of constituent signals from two different water pools: intra/extracellular water and myelin water. When using a multi spin-echo acquisition, the relaxation rate measured in each pool has been shown to depend on the orientation of the containing white matter fibre with respect to the main magnetic field. Here, we show an additional influence of the acquisition echo spacing on the apparent intra/extracellular rate relaxation rate, and using numerical simulation, we provide evidence that decoherence mediated by diffusion through local field inhomogeneities created by blood vessels cannot explain the observed orientation dependence.

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