Abstract #2861

Field dependence of T2* contrast in human substantia nigra

Malte Brammerloh^1,2, Evgeniya Kirilina^1,3, Renat Sibgatulin⁴, Karl-Heinz Herrmann⁴, Tilo Reinert^1,5, Carsten Jäger^1,6, Primož Pelicon⁷, Kerrin J. Pine¹, Primož Vavpetič⁷, Andreas Deistung⁸, Markus Morawski⁶, Jürgen R. Reichenbach⁴, and Nikolaus Weiskopf^1,5

¹Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²Leipzig University, Leipzig, Germany, ³Center for Cognitive Neuroscience Berlin, Freie Universität Berlin, Berlin, Germany, ⁴Medical Physics Group, Institute of Diagnostic and Interventional Radiology, University Hospital Jena, Jena, Germany, ⁵Felix Bloch Institute for Solid State Physics, Leipzig University, Leipzig, Germany, ⁶Paul Flechsig Institute of Brain Research, Leipzig University, Leipzig, Germany, ⁷Department for Low and Medium Energy Physics, Jožef Stefan Institute, Ljubljana, Slovenia, ⁸6University Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany

Synopsis

MRI holds high promise to diagnose Parkinson’s disease (PD) at clinical field strength B0. However, it remains unclear which B0 optimizes T2* contrast in substantia nigra, which provides high diagnostic accuracy. We used quantitative MRI at B0=1.5T-9.4T, MR microscopy, and histochemistry to characterize the field dependence of the major contributors to R2* (1/T2*): dopaminergic neurons, ferritin, and myelin. R2* maps were similar at B0=3T-9.4T, and all contributions scaled approximately linearly with B0. Hence, the contrast mechanisms are similar across currently available MRI field strengths in vivo, which informs the design of novel PD biomarkers.

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