Characterising Brain White Matter Alterations in Type 2 Diabetes: A UK Biobank Study of Neurite Orientation Dispersion and Density Imaging.
Abdulmajeed Alotaibi1,2,3, Amjad AlTokhis1,3, Anna Podlasek1,3, Chris Tench1,3, Sieun Lee1,3, Cris Constantinescu3,4,5, and Rob Dineen1,3,5
1Clinical Neurosciences, University of Nottingham, Nottingham, United Kingdom, 2Radiological Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, 3Precision Imaging Beacon of Excellence, Nottingham, United Kingdom, 4Neurology, Cooper University Hospital, Camden, NJ, United States, 5NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom
Type 2 diabetes is a metabolic disorder associated with subtle microstructural alteration of brain white matter. Diffusion tensor imaging (DTI) has been widely applied to evaluate white matter microstructural pathology in type 2 diabetes; however, DTI has limitations and lacks specificity. Using UK Biobank data, we applied neurite orientation dispersion and density imaging (NODDI) as an alternative advanced diffusion method to overcome DTI limitations. In this study, NODDI showed its potential role in giving a better biophysical characterisation of white matter neuroaxonal pathology in type 2 diabetes compared to DTI.
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