Abstract #2875

Characterising Brain White Matter Alterations in Type 2 Diabetes: A UK Biobank Study of Neurite Orientation Dispersion and Density Imaging.

Abdulmajeed Alotaibi^1,2,3, Amjad AlTokhis^1,3, Anna Podlasek^1,3, Chris Tench^1,3, Sieun Lee^1,3, Cris Constantinescu^3,4,5, and Rob Dineen^1,3,5

¹Clinical Neurosciences, University of Nottingham, Nottingham, United Kingdom, ²Radiological Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, ³Precision Imaging Beacon of Excellence, Nottingham, United Kingdom, ⁴Neurology, Cooper University Hospital, Camden, NJ, United States, ⁵NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom

Synopsis

Type 2 diabetes is a metabolic disorder associated with subtle microstructural alteration of brain white matter. Diffusion tensor imaging (DTI) has been widely applied to evaluate white matter microstructural pathology in type 2 diabetes; however, DTI has limitations and lacks specificity. Using UK Biobank data, we applied neurite orientation dispersion and density imaging (NODDI) as an alternative advanced diffusion method to overcome DTI limitations. In this study, NODDI showed its potential role in giving a better biophysical characterisation of white matter neuroaxonal pathology in type 2 diabetes compared to DTI.

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