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Abstract #2876

Longitudinal Fixel-Based Analysis of diffusion MRI in the zQ175 Huntington’s disease mouse model

Nicholas Vidas-Guscic1,2, Joëlle van Rijswijk1,2, Johan Van Audekerke1,2, Ben Jeurissen2,3, Stephan Missault1,2, Dorian Pustina4, Haiying Tang4, Roger Cachope4, Longbin Liu4, Celia Dominguez4, Ignacio Munoz-Sanjuan4, Annemie Van der Linden1,2, and Marleen Verhoye1,2
1Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium, 2µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium, 3Vision-Lab, University of Antwerp, Antwerp, Belgium, 4CHDI Management/CHDI Foundation, Princeton, NJ, United States


Huntington’s disease (HD) is a neurodegenerative disorder that affects motor and cognitive abilities. In this study, we present the outcome of a longitudinal multi-shell DWI investigation of the zQ175 HD mouse model using the diffusion tensor, diffusion kurtosis, and fixel-based analysis. This study reveals microstructural deficits at an early stage of the disease that mainly affect the diffusion tensor in corpus callosum and kurtosis in caudate putamen and grey matter, while fiber cross-section is reduced in major fiber bundles. At a late stage, many white matter fiber bundles show deficits that are indicative of differential myelination and potential axonal pathology.

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