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Abstract #2896

Anatomic changes during head and neck radiotherapy observed with automated MRI tracking

Eric Aliotta1, Yu-Chi Hu1, Peng Zhang1, Phil Lichtenwalner1, Amanda Caringi1, Natasha Allgood1, Jillian Tsai2, Kaveh Zakeri2, PengPeng Zhang1, Nancy Lee2, Laura Cervino1, and Michalis Aristophanous1
1Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States


Longitudinal MRI is an ideal tool for tracking anatomic changes that occur during head and neck radiotherapy. We have implemented an image tracking system that monitors volumetric changes in gross tumor volumes (GTV) and parotid glands to identify and alert of major changes early in treatment. In a cohort of 91 patients, this system identified systematic shrinkage of GTVs (9.2±8.3% per week) and parotids (3.1±3.7% per week) during treatment. Importantly, GTV changes observed in the first week of treatment were strongly predictive of larger changes that would occur later in the course (P<1x10-5, two-tailed t-test).

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