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Abstract #2898

Early response evaluation of neoadjuvant chemotherapy in locally advanced rectal cancer using T1 and T2 mapping

Xiaoling Gong1, Yu Shen2, Daguang Wen3, Mingtian Wei2, Xiaoxiao Zhang4, Xiaoyong Zhang4, Ziqiang Wang2, and Bing Wu3
1Departments of Radiology, West China Hospital, Sichuan University, Cheng du, China, 2Department of Clinical, West China Hospital, Sichuan University, Chengdu, China, 3Departments of Radiology, West China Hospital, Sichuan University, Chengdu, China, 4Philips Healthcare, China, Chengdu, China

Synopsis

Neoadjuvant chemotherapy can improve oncologic outcomes and overall survival rate. However, not all patients respond well during treatment, and continuous treatment will be painful, costly, and even increase risk of progression. Thus, early stratification of treatment response and screening of patients who may not be effective in treatment is very important. We investigated the value of T1 and T2 mapping MRI in response evaluation and found that T2 value showed a significant difference between groups of pre and 1-week post-treatment, while the T1 value had no statistical difference. T2 mapping may be a useful functional biomarker for early responses evaluation.

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