In this study, we investigated the 1H MR spectra quantification accuracy using basis sets with different linewidths and lineshapes in LCModel. Simulation results showed that the estimated metabolite concentrations depend on the linewidths and lineshapes of the basis sets as well as the spectral lineshape. This effect was validated with in vivo MR results. We conclude that the spectral lineshape and linewidth of basis sets should be carefully considered for accurate metabolite concentration estimations from short-TE 1H MR spectra using LCModel.
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