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Abstract #2899

Investigating the influences of spectral lineshape and linewidth in LCModel basis-sets on 1H MRS quantification at 7T

Ying Xiao1,2, Ivan Tkáč3, and Lijing Xin1
1Animal imaging and technology (CIBM), EPFL, Lausanne, Switzerland, 2Laboratory for Functional and Metabolic Imaging (LIFMET), EPFL, Lausanne, Switzerland, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States


In this study, we investigated the 1H MR spectra quantification accuracy using basis sets with different linewidths and lineshapes in LCModel. Simulation results showed that the estimated metabolite concentrations depend on the linewidths and lineshapes of the basis sets as well as the spectral lineshape. This effect was validated with in vivo MR results. We conclude that the spectral lineshape and linewidth of basis sets should be carefully considered for accurate metabolite concentration estimations from short-TE 1H MR spectra using LCModel.

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