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Abstract #2906

Constructing a Mesh-Based Template of the Liver is Consistent as a Function of Cohort Size in the UK Biobank

Marjola Thanaj1, Nicolas Basty1, Madeleine Cule2, Elena P Sorokin2, Jimmy David Bell1, Elizabeth Louise Thomas1, and Brandon Whitcher1
1Research Centre for Optimal Health, School of Life Science, University of Westminster, London, United Kingdom, 2Calico Life Sciences LLC, South San Francisco, CA, United States


Computational atlases provide many advantages in quantifying and modeling differences in the size and shape of internal organs between individuals in population imaging studies. A cohort of UK Biobank participants were analyzed to explore the consistency of templates, which is the average labeled image from a number of subjects constructed across different population sizes, and investigate whether this has an impact on the statistical analysis. We found no differences in our significance areas between templates. Although, for the statistical parametric mapping, a larger sample size that involves multiple hypothesis tests, results in a higher representative power.

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